MP582UK CALCIPHYLAXIS STUDY: INTERIM ANALYSIS
نویسندگان
چکیده
منابع مشابه
Calciphylaxis
however there are adequate discussions of epidemiology, phage anatomy, and the relation of viruses to cancer, as well as other topics which will intrigue the more medically oriented reader. A particularly valuable aspect of the book is that facts are discussed in relation to the research by means of which they were originally discovered or tested. The research is treated both by topic and chron...
متن کاملCalciphylaxis
Fig. 1. Dry gangrene of the fingers (A and B) and dusky red discoloration of the right great toe (C) are shown. Progression of the gangrene of the fingers (D and E) and development of gangrenous necrosis of the toes (F) are shown. Plain radiographs demonstrating marked vascular calcification of the hands and feet (G–J). Skin biopsy revealing calcification (K) and microthrombosis (L and M) of sm...
متن کاملCalciphylaxis
Figure 1. Right leg with painful ulcer demonstrating thrombosed blood vessels, saponified fat, and ischemic skin necrosis. DESCRIPTION A 56-year-old man presented with a wound of the right leg for 6 weeks that progressed from a linear ulceration with surrounding erythema to an excruciatingly painful ulcer with fat saponification and visible thrombosed vessels. His medical history was significan...
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Optimally, interim analyses are incorporated as part of the original study design. However, unforeseen circumstances may require a protocol to be amended after study initiation to include an interim analysis. It is important to strike a balance between selecting the optimum timepoint to perform the interim analysis based on the operating characteristics of the futility rule, and the logistics o...
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Pre-specified interim analyses may be performed to evaluate whether a clinical trial can be halted prematurely for overwhelming efficacy and/or futility. This approach is somewhat more complex when the primary endpoint is a survival analysis. This paper provides an overview of performing the initial calculations and actual interim analyses using SAS ® PROC SEQDESIGN and PROC SEQTEST, EAST ® sof...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2017
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfx177.mp582